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MASLD AI 07:18 AM
October 2025
In this educational session, Edith Johannes, NP, explores the connection between Metabolic Dysfunction–Associated Steatotic Liver Disease and MetALD, using a real-world case to illustrate how metabolic risk factors and alcohol use interact to accelerate liver fibrosis. Presented through the GHAPP MASLD/MASH Community Network and supported by Madrigal Pharmaceuticals, this talk covers diagnostic evaluation using FibroScan, CAP scores, and PEth testing, explains how to distinguish MASLD from MetALD and ALD, and highlights key management strategies including Mediterranean diet, exercise, weight loss, and alcohol cessation. Edith also discusses when to consider resmetirom therapy and HCC screening, emphasizing early intervention to prevent disease progression.
Related Webcast
Webcast: Comparing F3 and F4 Fibrosis With Anna Marie Hefner & Renee Pozza
November 2025
Join Anna Marie Hefner, RN and Renee Pozza, FNP-BC from Southern California Liver & GI Centers for a practical, case-based deep dive into advanced MASLD/MASH—what F3 vs F4 (cirrhosis) really means for staging, treatment, and surveillance. Using a 55-year-old patient scenario, they walk through interpreting FIB-4, FibroScan® (kPa + CAP), ELF, and routine labs; when to add ultrasound + AFP for HCC surveillance, and when to scope for esophageal varices. You’ll hear how they structure follow-up (from biweekly check-ins early to every 3 months), tailor diet and exercise to real-world habits, incorporate GLP-1s for weight and metabolic control, and consider resmetirom for eligible F2–F3 patients (not F4). The session also covers when to escalate to colonoscopy for alternative bleeding sources, and how to alternate US with triphasic CT/MRI in high-risk patients. Perfect for GI/hepatology APPs looking for a clear, actionable framework to manage fibrosis progression and optimize outcomes.
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Webcast: MASLD Pharmacotherapy With Milly Ng
September 2025
Pharmacotherapy for MASLD is rapidly evolving, and clinicians now have more tools than ever to guide treatment decisions. In this session, Milly Ng, NP at Tufts Medical Center in Boston, breaks down a practical framework for when to initiate treatment, how to select the right therapy, and what monitoring strategies to use. From lifestyle modification and statins to GLP-1 receptor agonists and the first FDA-approved liver-directed therapy, resmetirom, this discussion highlights both established and emerging options. You’ll also learn how GLP-1s can support weight loss and liver health, the evidence behind vitamin E and pioglitazone, and the pivotal Maestro NASH trial that secured accelerated approval for resmetirom. Whether you’re managing patients with obesity, diabetes, or advanced fibrosis, this overview offers actionable strategies to simplify complex decisions and improve outcomes in MASLD/MASH care.
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Webcast: MASLD vs MetALD With Janet Gripshover
September 2025
Janet Gripshover, NP, explains how to spot and manage metabolic dysfunction–associated steatotic liver disease (MASLD) and MASH—now the preferred terms replacing NAFLD. Through a real patient case, she shows how ultrasound findings, everyday risk factors (PCOS, high blood pressure, cholesterol, higher BMI), and an honest alcohol history point the way. Janet covers easy, non-invasive tests (FIB-4 blood test, FibroScan® stiffness and CAP scores) and when alcohol biomarkers (PEth, urine EtG) help confirm what’s really driving the liver damage. You’ll learn simple next steps: Mediterranean-style eating, resistance exercise, weight loss goals, and complete alcohol cessation to prevent progression to cirrhosis. She also notes when to start liver cancer (HCC) screening and what to document in the chart. Perfect for APPs and clinicians looking for a clear, practical MASLD/MASH workflow.
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Webcast: MASLD Pharmacotherapy With Allison Moser
November 2025
Join Allison Moser, NP, hepatology nurse practitioner at Rush University Medical Center, for a comprehensive update on pharmacotherapy in MASLD and MASH. In this MASLD Community Network session, Allison reviews the evolving treatment landscape—from lifestyle and metabolic management to the latest FDA-approved medications. Learn how resmetirom, the first and only approved therapy for MASH with stage 2–3 fibrosis, works as a thyroid hormone receptor-β agonist to improve liver fat and fibrosis. Discover the growing role of GLP-1 receptor agonists such as semaglutide in MASH management, as well as key insights on vitamin E, pioglitazone, and metabolic risk reduction through diet, exercise, and comorbidity control. This evidence-based discussion highlights the latest clinical trial data, practice guidelines, and real-world considerations for advanced practice providers managing metabolic liver disease. #MASH #MASLD #LiverHealth #Hepatology #APPeducation #Resmetirom #Semaglutide #FattyLiverDisease #NASH #MetabolicHealth
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Webcast: Non-Invasive Testing With Janet Gripshover
July 2025
In this in-depth and practical discussion, Janet Gripshover, NP from Cedars-Sinai in Los Angeles, explores the evolving role of non-invasive testing (NITs) in the diagnosis and risk stratification of MASLD (Metabolic dysfunction-associated steatotic liver disease) and MASH (Metabolic dysfunction-associated steatohepatitis). Drawing from real-world experience and a case study involving a 65-year-old patient with multiple cardiometabolic risk factors, she breaks down the latest 2025 approaches to fibrosis assessment—highlighting the use of FIB-4, ELF score, vibration-controlled transient elastography (FibroScan®), and MR elastography. Gryover also emphasizes how combining tests across modalities can improve accuracy and patient care while avoiding the risks of liver biopsy. Learn how liver stiffness, lab values, and clinical history all intersect to guide care and treatment decisions in patients with fatty liver disease. This session is part of the MASLD/MASH Community Network and is ideal for providers, specialists, and anyone interested in the forefront of liver disease management.
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Webcast: MASLD Basics With Lindsay Yoder
September 2025
Lindsay Yoder, PA, Indiana University, delivers a clear primer on the new MASLD/MASH nomenclature and how it fits within the broader Steatotic Liver Disease (SLD) spectrum—including MetALD and alcohol-associated liver disease—so clinicians can label etiology correctly and tailor care. She walks through a practical primary-care algorithm: start with FIB-4 (use 1.3 and 2.67 cutoffs), then add ELF and/or VCTE/FibroScan (LSM and CAP) to risk-stratify fibrosis, refer when intermediate/high risk, and reserve biopsy for discordant cases. The session reviews staging (F0–F4), when to escalate to cirrhosis management and HCC/variceal surveillance, and highlights the impact of the first FDA-approved therapy (resmetirom) for MASH with F2–F3 fibrosis, alongside multidisciplinary lifestyle and cardiometabolic optimization. Perfect for APPs, PCPs, GI, and hepatology teams seeking a concise “basics to bedside” roadmap.
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Webcast: MASLD vs MetALD With Elizabeth Alqueza
October 2025
Elizabeth Alqueza, PA-C, explains MASLD and MetALD using a real patient case—covering risk factors (PCOS, BMI, HTN, lipids), how to stage disease with FibroScan/Liver Stiffness and CAP, and why alcohol plus metabolic dysfunction accelerates fibrosis. Learn practical steps: PEth biomarker to uncover alcohol use, lifestyle therapy (Mediterranean diet, weight loss), when resmetirom may be considered, and HCC surveillance for advanced fibrosis.
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Webcast: Non-Invasive Testing With Stacie Egan
October 2025
Stacie Egan, FNP-C, discusses how non-invasive testing is transforming the way clinicians evaluate and manage MASLD/MASH. Using a real patient case, she explains how to interpret key tools like FIB-4, ELF, FibroScan (VCTE), and MR elastography to assess liver stiffness, steatosis, and fibrosis severity. Stacie also highlights practical considerations for accurate testing, when to order secondary assessments, and how to combine results with clinical judgment for optimal patient care. Learn how non-invasive diagnostics guide treatment decisions, support early intervention, and improve outcomes in metabolic liver disease.
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Webcast: Comparing F3 and F4 Fibrosis With Jennifer Geremia
August 2025
In this GHAPP MASLD Community Network session, Jennifer Geremia, PA-C from Boston, discusses the critical differences between F3 fibrosis and F4 cirrhosis in patients with MASLD (Metabolic Associated Steatotic Liver Disease) and MASH (Metabolic Associated Steatohepatitis). Using a detailed case study, she outlines how non-invasive tests (NITs) such as FIB-4, FibroScan, CAP score, and ELF testing can help differentiate fibrosis stages and guide patient management. The discussion highlights when to consider advanced testing, the role of resmetirom (Rezdiffra) in eligible F2–F3 patients, and why treatment strategies differ for those with F4 cirrhosis, including the need for HCC surveillance, portal hypertension evaluation, and variceal screening. Jennifer also emphasizes lifestyle modifications, metabolic risk factor control, and multidisciplinary care as essential components of managing advanced liver disease. This presentation provides valuable insights for GI, hepatology, and primary care providers navigating the nuances of fibrosis staging and treatment decisions in 2025.
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Webcast: Lifestyle Management With Allysa Saggese
August 2025
Join Allysa Saggese, NP, from Weill Cornell Medicine in New York City, for an insightful and practical discussion on lifestyle management for MASLD and MASH, presented through the GHAPP MASLD/MASH Community Network, sponsored by Madrigal Pharmaceuticals. In this case-based presentation, Allysa walks viewers through the non-pharmacologic strategies used to manage Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), highlighting the role of nutrition, physical activity, and patient-centered counseling. Using a real-world example of a 65-year-old patient with obesity, diabetes, and steatosis, Allysa demonstrates how to assess fibrosis risk through non-invasive testing like FIB-4 and FibroScan, and explains how lifestyle modifications remain central to slowing disease progression—even in the era of advanced therapeutics. The session explores the importance of motivational interviewing, cultural dietary preferences, and how to structure effective, individualized conversations around reducing sugar intake, increasing movement at home, and achieving sustainable 5–10% weight loss to improve liver histology. Allysa also breaks down the metabolic interplay between central adiposity, insulin resistance, and liver inflammation, and shares counseling tips to build patient trust and long-term engagement. Whether you're a GI or hepatology provider, this session delivers real-world guidance to help empower patients to reverse early liver damage through everyday lifestyle changes.
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