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MASLD AI 07:18 AM
November 2025
Join Erin Parkinson, APRN, FNP-C for a clear, case-based explainer on diagnosing MetALD versus MASLD. Using a typical patient scenario, Erin shows how to interpret FibroScan (kPa/CAP), translate alcohol “servings” into grams, and use PEth and screening tools (e.g., AUDIT-C, lab clues) to objectively quantify alcohol intake. You’ll learn practical next steps—Mediterranean diet, exercise/weight loss, alcohol abstinence, and when F3 fibrosis should prompt HCC screening—plus how to apply standardized criteria so care and clinical trials compare “apples to apples.”
Related Webcast
Webcast: MASLD vs MetALD With Maly Tiev
November 2025
In this educational session, Maly Tiev, NP from NYU Langone Health, explores the evolving understanding of metabolic dysfunction–associated steatotic liver disease (MASLD) and metabolic dysfunction–associated alcohol-related liver disease (MetALD). Drawing on over 25 years of hepatology experience, she uses a real-world case to walk through the latest definitions, diagnostic criteria, and management strategies for patients with overlapping metabolic and alcohol-related liver disease. Maly explains how alcohol intake interacts with metabolic risk factors such as obesity, diabetes, and hypertension to accelerate fibrosis progression, and highlights the role of non-invasive testing—including FibroScan and the PEth test—in accurate diagnosis. The discussion also covers the clinical significance of F3 fibrosis, lifestyle interventions like the Mediterranean diet, and when to consider pharmacologic treatment such as resmetirom for patients with advanced disease. Watch to better understand how to identify, classify, and manage MASLD and MetALD in clinical practice.
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Webcast: Non-Invasive Testing With Tina Gregg
October 2025
In this session, Tina Gregg, NP-C, reviews non-invasive testing (NITs) for MASLD and MASH, using a real-world case to show how to assess risk and stage fibrosis without biopsy. Learn when to use FIB-4, ELF, FibroScan (VCTE), and MR elastography, how to interpret cutoffs, and when to refer to hepatology. Practical takeaways include triaging indeterminate FIB-4 results, recognizing test limitations, and counseling patients on lifestyle and follow-up. Presented via the GHAPP MASLD Community Network.
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Webcast: MASLD Pharmacotherapy With Kelly Smeester
August 2025
Join Kelly Smeester, MMS, RD, PA-C, from South Denver Gastroenterology for an in-depth pharmacologic review of current and emerging treatment options for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and MASH (Metabolic Dysfunction-Associated Steatohepatitis), as part of the GHAPP MASLD Community Network. This session outlines a comprehensive treatment strategy focused on three key goals: promoting weight loss, reducing cardiovascular risk, and targeting liver-specific interventions. Kelly highlights lifestyle and pharmacologic interventions including GLP-1 receptor agonists, GIP/GLP-1 dual agonists, and bariatric surgery, while exploring evidence-based guidance for treating comorbidities like type 2 diabetes, hypertension, and dyslipidemia. She dives into the latest data on vitamin E, pioglitazone, and the newly FDA-approved Resmetirom (Rezdiffra)—a thyroid hormone receptor beta agonist indicated for adults with non-cirrhotic NASH and F2–F3 fibrosis. Learn about the results from pivotal clinical trials like ESSENCE, PIVENS, and MAESTRO-NASH, the importance of NAFLD activity scoring, as well as dosing strategies, adverse effects, and drug interactions to consider when using Resmetirom. The session also explores practical monitoring approaches including FibroScan, MRI-PDFF, and ELF scores, with an outlook on evolving treatment duration and insurance coverage considerations. Whether you're a hepatology provider or part of a multidisciplinary care team, this presentation offers critical insights to optimize MASH treatment pathways today and in the future.
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Webcast: MASLD vs MetALD With Valerie Shin
September 2025
Valerie Shin, NP from UCLA Health’s Pfleger Liver Institute, hosts a clear, practical overview of MASLD, MASH, and mixed-etiology MET-ALD for the GHAPP MASLD Community Network (sponsored by Madrigal). Through a common patient case, she explains how to recognize steatotic liver disease, why getting an accurate alcohol history matters, and how non-invasive tools (like FibroScan and alcohol biomarkers) help confirm what’s driving liver injury. You’ll hear straightforward guidance on counseling patients: heart-healthy/Mediterranean-style eating, sustainable weight loss, regular aerobic and resistance exercise, and complete alcohol cessation—plus when to consider specialty referral and ongoing surveillance. Perfect for APPs and GI clinicians seeking a simple, patient-centered approach to preventing progression from fatty liver to advanced disease.
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Webcast: Non-Invasive Testing With Sherona Bau
July 2025
In this engaging and highly informative GHAPP MASLD Community Network session, Sherona Bau, NP, walks attendees through a practical overview of non-invasive testing (NIT) for evaluating liver health in patients with MASLD (Metabolic dysfunction-associated steatotic liver disease) and MASH (Metabolic dysfunction-associated steatohepatitis). Drawing on real-world clinical experience, Sherona explains why non-invasive testing is essential for identifying fibrosis risk in a population where liver steatosis is prevalent in up to 30% of U.S. adults. Through the case of a 65-year-old Hispanic male named Albert, Sherona demonstrates how to interpret and apply tools such as FIB-4, FibroScan (VCTE and CAP score), ELF (Enhanced Liver Fibrosis) test, and MR Elastography (MRE). She highlights their respective strengths, limitations, clinical cut-offs, and insurance-related considerations. The session also covers when to order tests, how to assess data quality (e.g., IQR/median ratio in VCTE), and when to escalate care to hepatology or cardiology. Whether you are a primary care provider, endocrinologist, or hepatology specialist, this talk delivers practical algorithms and decision-making pathways for managing MASLD, improving early detection of fibrosis and cirrhosis, and integrating cardiovascular risk assessment into liver care. Sherona also emphasizes the importance of alcohol use history, metabolic syndrome risk factors, and annual NIT follow-up in patients at risk for disease progression.
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Webcast: MASLD vs MetALD With Jeremy Davis
September 2025
In this MASLD Community Network talk, Jeremy Davis, NP, uses a real-world case to clarify how to differentiate MASLD from MetALD, interpret alcohol exposure, and stage disease with non-invasive tools. He explains standard drink equivalents (≈14 g ethanol) and why accurate histories plus objective biomarkers matter, then walks through labs and elastography (FibroScan kPa/CAP) showing F3 fibrosis with severe steatosis. You’ll learn a practical workflow to rule out alternative etiologies, quantify alcohol use, and understand how metabolic risk plus alcohol accelerates fibrosis and decompensation risk. Jeremy outlines counseling pearls (abstinence recommendations, Mediterranean-style diet, weight loss, activity), eligibility considerations for resmetirom in non-cirrhotic MASH (F2–F3), and when to start HCC surveillance. Watch to strengthen your staging, counseling, and treatment decisions for patients who fall along the MASLD–MetALD spectrum.
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Webcast: MASLD vs MetALD With Whitney Steinmetz
November 2025
Join Whitney Steinmetz, NP for a practical, case-based walkthrough of the updated steatotic liver disease nomenclature—MASLD, MASH, and ALD/MetALD—and how to apply it in clinic. Using a common scenario, she covers risk stratification with FIB-4 and FibroScan (kPa/CAP), when to order PEth to quantify alcohol use, and why F3 warrants HCC screening and vaccinations. You’ll get actionable tips on counseling for weight loss and alcohol reduction, evaluating supplements, addressing cardiometabolic risks (A1C, triglycerides, BP), and considering resmetirom in appropriate non-cirrhotic patients.
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Webcast: Lifestyle Management With Lisa Richards
July 2025
Join Lisa Richards, FNP-BC, from UC San Diego Health, as she leads a powerful educational session on the lifestyle management of MASLD (Metabolic Dysfunction–Associated Steatotic Liver Disease) in this GHAPP MASLD/MASH Community Network event, sponsored by Madrigal Pharmaceuticals. Through a compelling clinical case study, Lisa walks viewers through a step-by-step approach to diagnosing MASLD, assessing fibrosis risk using noninvasive tools like FIB-4 and FibroScan, and implementing guideline-based interventions. Learn how to counsel patients on culturally sensitive dietary modifications, physical activity strategies, and behavior change techniques that improve outcomes. This session also explores the clinical relevance of weight loss thresholds, Mediterranean-style eating plans, and the importance of patient-centered goal setting. Whether you’re a provider managing metabolic liver disease or looking to integrate newer therapies like resmetirom, this video offers practical tools to empower sustainable change and improve liver health.
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Webcast: Comparing F3 and F4 Fibrosis With Maly Tiev
September 2025
Maly Tiev, NP, reviews two real-world cases to explain the critical differences between F3 advanced fibrosis and F4 cirrhosis in patients with MASLD/MASH, and how accurate staging changes treatment, prognosis, and surveillance strategies. Using non-invasive tests (NITs) such as FIB-4, FibroScan/Liver Stiffness (kPa), CAP, and the ELF test, she demonstrates how concordant results can guide management without biopsy, when discordant results may require further imaging or histology, and why platelet count and bilirubin trends are key for identifying cirrhosis. For patients with F3, Maly highlights the importance of lifestyle modification with 7–10% weight loss, diet and exercise counseling, optimization of type 2 diabetes and lipid control, potential use of GLP-1 therapy, and when resmetirom (FDA-approved for MASH with F2–F3 fibrosis) may be considered, along with repeat NITs for monitoring. For patients with F4, management shifts to cirrhosis care, including twice-yearly HCC surveillance (ultrasound ± AFP), variceal screening guided by liver stiffness and platelet thresholds, and strict emphasis on alcohol avoidance and cardiometabolic risk reduction, noting that resmetirom is not used in cirrhotic patients. This case-based discussion provides clinicians, APPs, and hepatology teams with practical tools to approach staging, risk stratification, and surveillance in MASLD/MASH.
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Webcast: Non-Invasive Testing With April Morris
July 2025
In this educational presentation, April Morris, NP—an experienced provider in both liver disease and endocrinology—guides viewers through the evolving landscape of non-invasive testing (NITs) for diagnosing and managing patients with MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) and MASH. Using the case of a 65-year-old male with metabolic co-morbidities and suspected liver disease, Morris reviews how to effectively apply tools like the FIB-4 score, ELF test, and FibroScan (VCTE) to assess fibrosis risk and stratify patients. She compares imaging modalities including transient elastography, MR elastography (MRE), and shear wave elastography, offering practical considerations such as patient eligibility, test accuracy, and insurance barriers. The discussion emphasizes the importance of interpreting NITs within clinical context—highlighting how to determine risk, guide patient counseling, and establish a follow-up plan for low-risk patients. This session also reinforces the role of primary care in longitudinal liver health management and directs providers to resources available through the GHAPP MASLD & MASH Community Network.
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