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Featured MASLD/MASH Educators

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Elizabeth Alqueza

PA-C

Elizabeth Alqueza, PA-C is a board certified Physician Associate at Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts. She graduated from the University of Florida in 2004 with a Master of Physician Assistant Studies degree and subsequently completed the AASLD NP/PA Clinical Hepatology Fellowship. Elizabeth has worked in a variety of inpatient and outpatient settings with a strong commitment to patient care. Currently working at BIDMC Liver Center, Elizabeth has 5 years of dedicated experience in Hepatology. Her practice focuses primarily on steatotic liver disease, including Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH). Elizabeth is an active member of Gastroenterology and Hepatology Advanced Practice Providers.

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Michelle Barnett

PA-C, MPAS, DFAAPA

Michelle Barnett is a highly experienced physician assistant specializing in patient-focused and evidence-based hepatology at Peak Gastroenterology Associates in Colorado Springs, Colorado. The most rewarding part of her position includes educating patients and collaborating with other GI advanced practice providers to enhance care for the growing MASLD/MASH population. She is now a subinvestigtor for hepatology clinical trials with Peak in Colorado Springs. With over 30 years in the GI and liver communities, she has held leadership roles, including serving as President of the Colorado Academy of Physician Assistants (CAPA) and receiving CAPA's Physician Assistant of the Year award. She is a national speaker and has given lectures for the AAPA, GHAPP and AANP. A graduate of Wichita State University and the University of Nebraska, Michelle has been recognized with the DFAAPA distinction and honors such as the Crohn’s and Colitis Foundation's IBD internship and the International Foundation for Gastrointestinal Disorders Ally Award. Passionate about holistic care, she incorporates lifestyle strategies like nutrition, yoga, and meditation into her practice. Outside of work, Michelle enjoys hiking, travel, musical theater, and supporting her favorite Colorado sports teams.

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Sherona Bau

NP

Sherona Bau graduated from University of California, Los Angeles in 2008, with Master of Science in Nursing dual program specialized in Acute Care Nurse Practitioner and Clinical Nurse Specialist. In 2010, she has joined UCLA Pfleger Liver Institute and Asian Liver Cancer Center working as an outpatient Nurse Practitioner specializing in liver diseases including viral hepatitis, hepatobiliary diseases, alcohol related liver diseases, Metabolic Dysfunction-Associated Steatotic Liver Disease/Steatohepatitis, autoimmune liver diseases, and hepatocellular carcinoma. Since 2016, she has been a guest lecturer at UCLA School of Nursing for Master Entry Clinical Nurse (MECN) and MSN Adult/Gero Acute Care program. She is also a preceptor for Adult/Gero Acute Care Program. She participated in Hepatitis C Screening in the Community Churches to promote awareness of hepatitis C and the importance of treatment of hepatitis C. She also participates in Patient Symposium at UCLA to give a lecture to update care of the liver transplant patients. She is also a faculty of Gastroenterology Hepatology Advanced Practice Provider (GHAPP) since 2018 and a speaker for both GHAPP National meeting and Regional GHAPP in Los Angeles. Since 2013, she has published total 14 research papers and case report including the most recent three are Recommendations for the Management of MASH by Advanced Practice Providers in the US, Clinicians and Patients Confront Practical Issues in Wilson Disease, and Overview of chronic Hepatitis B management.

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Maribeth Capuno

DNP, RN, ANP-BC

Maribeth Capuno obtained her Master of Science in Nursing from Emory University in 1996. She was then certified as an Adult Nurse Practitioner. She worked as a Nurse Practitioner in Cardiology for over 20 years, specializing in Heart Failure. In 2019, she advanced her education by obtaining her Doctor of Nursing Practice from the University of Virginia. In 2021, she relocated to Richmond Virginia and took a position in the Hepatology department at the Richmond Veteran's Affairs Medical Center. In this position, her focus has been on patients with MASLD/MASH throughout the spectrum of their disease. She works with her patients to develop an individualized plan of care to assist them in controlling their metabolic conditions which are contributing to their liver disease. She also is a Sub-Investigator on multiple MASLD/MASH clinical trials.

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Summer Collier

MSN, FNP-BC

Summer Collier is a nurse practitioner with advanced expertise in hepatology and a strong commitment to evidence-based, multidisciplinary care. At UC San Diego Health, she provides comprehensive management for patients with chronic liver disease, including viral hepatitis, autoimmune hepatitis, alcohol-associated liver disease, and metabolic dysfunction–associated steatotic liver disease (MASLD). Collier is actively engaged in clinical research and has participated in multidisciplinary studies on liver fibrosis, steatosis, and treatment protocols for hepatitis C and alcohol use disorder. Her scholarly work focuses on improving transitions of care for patients with cirrhosis and expanding access to pharmacologic treatments for patients with alcohol use disorder. A recognized leader in the field, Collier has presented at national conferences including The Liver Meeting (AASLD), Digestive Disease Week (DDW), and GHAPP, speaking on topics such as cirrhosis care, hepatology red flags, and advanced practice provider leadership. She previously served as Chair of the Advanced Practice Council at UC San Diego Health, driving initiatives that elevated APP visibility and impact within the organization. Before joining UC San Diego Health, she was a family nurse practitioner and HIV specialist with Family Health Centers of San Diego. She also has prior experience as a registered nurse. Collier completed a Master of Science in Nursing degree from University of San Diego and will complete the Doctor of Nursing Practice degree from University of California, Los Angeles in June 2025. She is certified by the American Nurses Credentialing Center.

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Jessica Crimaldi

MSN, NP-C, CMSRN

Jessica Crimaldi, MSN, APRN,CNP, CMSRN was born and raised in the greater Cleveland area. She attended Cleveland State University for her BSN; during her time at CSU she had the opportunity to work at The Cleveland Clinic Foundation in a 3-year internship entitled the "Nursing Experiential Program." In this role she had the opportunity to learn many of the roles on a typical nursing unit while working 1 year as a Unit Secretary, 1 year as a Nurse Assistant and 1 year as a Nurse Intern. She started her nursing career on an inpatient Internal Medicine and Telemetry Teaching Unit where she worked as an RN while completing her MSN at the University of Akron. Since graduation in 2015 she has worked as a Nurse Practitioner in the Department of Gastroenterology, Hepatology and Nutrition seeing inpatients with gastrointestinal and liver disorders at The Cleveland Clinic Foundation. In addition, to her clinical role, she is also the Manager for over 50 Gastroenterology, Hepatology and Nutrition APPs. She is the Co-Director for the nation's first Inflammatory Bowel Disease APP Fellowship which is in its third year. She has presented nationally and published in The Journal for Nurse Practitioners (JNP). She is Faculty for Gastroenterology and Hepatology Advanced Practice Providers (GHAPP) National Organization and Milestone APP. When she is not busy with work Jessica is a wife, parent to 2 young children and dog mom. She is a foster parent and passionate about improving the foster care system. She enjoys being outdoors, hiking and spending time with family and friends.

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Jeremy Davis

ACNP-BC

Jeremy Davis ACNP is a board-certified acute care nurse practitioner who has been practicing in the focus of hepatology at GastroIntestinal Specialists A.M.C. since 2012. Jeremy’s areas of interest include MASLD, MASH, Hepatitis B, Hepatitis C, cholestatic liver disease, and autoimmune liver disease. Jeremy has been an active faculty ambassador of Gastroenterology & Hepatology Advanced Practice Providers (GHAPP) since 2019 and is a lecturer at both regional and national conferences. Jeremy is also an Associate member of the American Association for the Study of Liver Diseases (AASLD) since 2014. Jeremy received his Bachelor of Science degree and Master of Science Degree in Nursing from Northwestern State University in Natchitoches, Louisiana. Jeremy’s hobbies include spending time with his family, cooking and traveling.

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Sarah Dawkins

FNP-C, MSN, RN

Sarah Dawkins, FNP-C, is a family nurse practitioner specializing in general and transplant hepatology at Duke University Medical Center, where she has practiced since 2017. She holds a BS in Biology and a BA in Romance Languages from the University of North Carolina at Chapel Hill. Sarah completed the Accelerated Bachelor of Science in Nursing (ABSN) program at Duke University and worked in the Neuroscience ICU at Duke while earning her Master of Science in Nursing (MSN). She became a certified family nurse practitioner in 2015 and initially worked in a private gastroenterology practice before joining Duke Gastroenterology. Her clinical interests include autoimmune liver disease, transplant hepatology and metabolic dysfunction-associated steatotic liver disease (MASLD). Sarah currently serves as the Advanced Practice Provider (APP) Team Lead for the GI Division at Duke. Outside of work, she enjoys traveling, trying new restaurants, attending fitness classes, cheering on the UNC Tar Heels, and spending time with her three young children and their orange cat, Zeus.

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Anthony Derencius

MPAS, PA-C

Anthony Derencius, PA-C is a former U.S. Army medic and a 2010 honor graduate of the military’s Interservice Physician Assistant Program. During his 11 years in the Army, he provided care to patients and soldiers around the world, including deployments to Afghanistan and Iraq. After leaving the Army, PA-C Derencius focused his clinical career in the gastroenterology and hepatology field. He has worked in private practice GI in Hawaii and in both general and transplant hepatology in San Antonio, gaining extensive outpatient and inpatient experience. In 2024, he joined Pinnacle Clinical Research, bringing a wealth of clinical expertise to his role as an investigator in many clinical trials for MASLD and other liver diseases. In 2018, he completed a one-year American Association for the Study of Liver Disease (AASLD) Foundation NP/PA Clinical Hepatology Fellowship. He is also an active member of several medical societies, including the American College of Gastroenterology (ACG) and the AASLD.

Stacie Egan

DNP, FNP-C

Stacie Egan, DNP, FNP-C, is a Family Nurse Practitioner specializing in gastroenterology, practicing with the Ogden Clinic in Utah. Born and raised in the Ogden area, she completed her Bachelor of Science in Nursing at Weber State University, graduating summa cum laude. She went on to earn her Master of Science in Nursing from the University of Cincinnati, and most recently her Doctor of Nursing Practice degree, which she obtained in 2022. Stacie joined Ogden Clinic in 2017 and works primarily through the Layton Specialty location, where she focuses on digestive health, disease prevention, and helping patients improve quality of life through clinical care and education. Her passion for gastroenterology stems from her strong belief in the impact of preventative health and the importance of gut health in overall wellness. Beyond her clinical work, Stacie values a patient-centered approach—listening to patients, addressing their concerns, and applying her knowledge to support them in achieving better health outcomes. She resides locally, is married, and in her free time enjoys Utah’s outdoor lifestyle, including trail running, enjoying natural areas like Snowbasin, and participating in the Ogden Marathon.

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Melissa Franco

PA-C, MMS

Melissa Franco is a Physician Associate at the University of Miami- specializing in the management of patients with liver diseases, ranging from acute hepatitis to complex chronic conditions such as cirrhosis and liver cancer. With a strong focus on MASH, autoimmune hepatitis, PBC, viral hepatitides, and cirrhosis- Melissa is dedicated to delivering compassionate, comprehensive care tailored to each patient's unique needs. She is deeply committed to patient education, and strives to empower individuals to take an active role in their health journey, fostering collaboration, and confidence at every stage of care.

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Jennifer Geremia

MPAS, PA-C

Jennifer Geremia, MPAS, PA-C, is a practicing Physician Assistant in outpatient Gastroenterology at Brigham and Women's Hospital in Boston. With GI experience for 15 years including community GI care in RI and currently tertiary care. In addition to clinical practice she enjoys educating both her peers and future PAs. Jennifer currently teaches at UNE, MCPHS and MGH PA programs. She is also on the Education committee and faculty for GHAPP and is actively working on the AGA APP task force as well as an APP contributor to ASGE .

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HoChong Gilles

DNP, FNP-BC, AF-AASLD

HoChong Gilles earned dual Bachelor of Science degrees in Biology and Nursing, followed by a Master of Science in Nursing from Virginia Commonwealth University. In 2018, she completed her Doctorate in Nursing Practice at the University of Virginia. With over 25 years of experience as a Nurse Practitioner specializing in hepatology, Dr. Gilles currently serves as the Clinical Program Director for the Gastroenterology and Hepatology Division and Assistant Director of GI Research in Richmond, Virginia. Her clinical and research interests encompass metabolic dysfunction associated steatotic liver disease (MASLD/MASH), portal hypertension, liver transplantation, and hepatocellular carcinoma. An active member of the liver disease community, she is proud to hold the designation of Associate Fellow with the American Association for the Study of Liver Disease (AASLD).

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Elizabeth Goacher

PA-C

Elizabeth Goacher is a Physician Assistant with Duke University Medical Center, Department of Medicine, Gastroenterology Division, Duke Liver Center, April 2001 to the present. Her pronouns are she/her. She is currently engaged in full time clinical practice in Hepatology. Her clinical work encompasses the full spectrum of liver disease patient population, from early stage disease to end of life, with a particular interest in portal hypertension. She served as Team Lead for the Duke Division of Gastroenterology Advanced Practice group of 25 Advanced Practice Providers 2014-2023. She is also lecturer and preceptor at Duke University School of Medicine Physician Assistant Program. Elizabeth graduated from the Duke University School of Medicine Physician Assistant Program in 1998 after earning her Bachelor of Arts from University of North Carolina at Chapel Hill in 1991. She is past Chair of the Hepatology Associates Committee of the American Association for the Study of Liver Diseases and was a member of the inaugural class of Associate Fellows of AASLD in 2020. When she is not at work, she maintains a health boundary from technology (aka EPIC) and spends as much time outdoors as possible. When asked to design and implement her dream job, she would own and operate a cocktail and tapas venue while instructing fitness classes on a large piece of lakeside property in North Carolina alongside her canine rescue, foster and retraining agency.

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Ellie Gonyeau

NP

Ellie Gonyeau is a board-certified Nurse Practitioner specializing in gastroenterology at Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts. She earned her Nurse Practitioner degree from Simmons University and has been practicing since 2020. Ellie is affiliated with Cape Cod Hospital and Beth Israel Deaconess Medical Center, providing comprehensive care to patients with various gastrointestinal conditions. She is committed to delivering patient-centered care and building long-term, trusting relationships with her patients.

Tina Gregg

NP-C

Tina Marie Gregg, NP-C, is a board-certified nurse practitioner specializing in gastroenterology with a particular focus on liver disease. She serves as The Liver Clinic Specialist at GI Associates & Endoscopy Center in Flowood, Mississippi, where she provides comprehensive care for patients with conditions such as cirrhosis, fatty liver disease, hepatitis, and other chronic liver disorders. Tina earned her Bachelor of Science in Nursing from Mississippi College and has been certified by the American Academy of Nurse Practitioners since 2007. At GI Associates, she is actively involved in both clinic visits and procedural care, coordinating diagnostic evaluations, treatment plans, and long-term disease management. Known for her compassionate and thorough approach, Tina is dedicated to helping patients understand their conditions and treatment options while ensuring close follow-up and ongoing support.

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Janet Gripshover

DNP, MBA

Janet Gripshover, DNP, MBA, AF-AASLD, is a highly experienced Family Nurse Practitioner and Nurse Manager for Cedars-Sinai’s Liver Transplant Program in Los Angeles. With over 15 years of clinical and leadership expertise in hepatology, Dr. Gripshover is recognized for her commitment to advancing the role of Advanced Practice Providers (APPs) in liver care. She has led numerous initiatives to foster APP education and collaboration, including founding the APP HCV Consortium in Baltimore, MD, and creating the GI APP Grand Rounds series at Geisinger Wyoming Valley in Wilkes-Barre, PA. In addition to speaking at national conferences, Dr. Gripshover has developed and delivered a wide range of educational and professional development seminars for non-physician providers across the country. An advocate for patient-centered innovation, she also founded and moderated the first hospital-sponsored Facebook support group for liver transplant recipients — a project that earned her the New Media Award for Healthcare from the Baltimore Business Journal and national recognition. Dr. Gripshover is an active member of the American Association for the Study of Liver Diseases (AASLD), where she has served on the Hepatology Associates Committee and the Women’s Initiatives Committee, helping launch the AASLD Women’s Leadership Program. She currently serves as Vice Chair of AASLD’s Hepatology Associates Special Interest Group and is also a member of the Hepatology Associates Committee for the American College of Gastroenterology (ACG).

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Christina Hanson

FNP-C

Christina Hanson is a nurse practitioner in Gastroenterology and Hepatology at South Denver GI, with nearly 20 years of clinical practice. She is a course director and board of trustee for GHAPP. An active researcher with extensive leadership and teaching experience, she is a champion of evidence-based practice, data-driven care delivery, interdisciplinary collaboration, and quality patient care. Christina is committed to amplifying professional development, growth, and contributions of advanced practice.

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Patrick Horne

ARNP

Patrick M. Horne, MSN, APRN-BC, FNP, AF-AASLD is the Assistant Director of Clinical Hepatology Research and Clinical Programs Coordinator at the University of Florida’s Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition. He holds bachelor's and master's degrees from the University of Florida College of Nursing. His research focuses on hepatology clinical trials, including viral hepatitis, MASH, autoimmune hepatitis, cholestatic liver disease, and HCC. He has published extensively in clinical hepatology and has presented at major conferences such as AASLD, AGA NP/PA, and GHAPP.

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Lavinia Iordache

PA-C

Lavinia Iordache earned her Masters of Clinical Medical Science from Barry University in Miami and she has been practicing as a Physician Associate in the field of Hepatology for the past 10 years. She completed a one year AASLD fellowship under the guidance of her supervising physicians and she continues to provide care to a complex patient population in an academic environment. She previously attended Medical School in her home country of Romania and graduated Magna Cum Laude from Florida International University with a Bachelor Degree in Biochemistry. She holds a NCCPA certification and is a proud member of several professional associations as well as animal welfare organizations. Her dedication to helping people with liver disease extends to both inpatient and outpatient settings and she has been expanding her clinical practice to include Internal Medicine as well as General Gastroenterology. She values a holistic and patient-centered approach to care and is a big advocate for patient education, always striving to connect with her patients to promote understanding of diseases, build trust and improve outcomes through collaboration. Lavinia is fluent in Spanish and particularly enjoys communicating with her Latin patient population in South Florida as she has a lifelong interest in learning different dialects and connecting with people of various ethnic backgrounds. In her free time, Lavinia particularly enjoys exploring new destinations, she has taste for adventures, unique art galleries and museums, loves cooking and entertaining and she is intentional about pursuing a holistic lifestyle through conscientious choices for a mindful integration of mind, body and soul.

MASLD/MASH Learning Center

Latest News & Blogs

Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study

October 2025

CONCLUSION: Diagnostic performance of common non-invasive tests for fibrosis in MASLD varies across the world. In the large multinational G-MASLD sample, the most accurate NITs were Agile-3+ and Agile-4 composite scores.

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Bedside FibroScan as a Point-of-care Tool for Quantification for Cirrhosis: A Single-center Prospective Observational Study from Western India

October 2025

CONCLUSION: Bedside FibroScan® offers a highly accurate, rapid, and noninvasive method for quantifying liver fibrosis and cirrhosis in clinical practice. Its integration into routine care could substantially improve management for patients at risk of liver disease.

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Real-world work productivity is impaired in people with metabolic dysfunction-associated steatotic liver disease in the USA

October 2025

CONCLUSIONS: Activity impairment was greater in participants with high-risk MASH, whereas overall work impairment was comparable, almost 20%, in low- and high-risk MASH. Non-specific symptoms of fatigue, sleep disturbance, and general weakness associated with MASH and other conditions predicted work impact in low-risk MASH. Thus, early detection and management of MASH could ameliorate work impairment.

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Diet and Lifestyle Interventions in Metabolic Dysfunction-Associated Fatty Liver Disease: A Comprehensive Review

October 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), have become the leading causes of chronic liver disease worldwide, with increasing rates of cirrhosis, hepatocellular carcinoma, and cardiovascular complications. Pathogenesis involves a complex interplay of dietary excess, sedentary lifestyle, insulin resistance, adipose tissue dysfunction, and alterations in the gut microbiome, which collectively...

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CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c

October 2025

Increased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Human carboxylesterase 1 (CES1) regulates TG storage and secretion in hepatocytes, but the mechanism remains to be elucidated. We performed studies in rat hepatoma McArdle RH7777 cells stably transfected with CES1 cDNA and in Ces1d-deficient mice using a variety of biochemical,...

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Myeloid-Specific STAT3 Deletion Aggravates Liver Fibrosis in Mice Fed a Methionine- and Choline-Deficient Diet via Upregulation of Hepatocyte-Derived Lipocalin-2

October 2025

The signal transducer and activator of transcription 3 (STAT3) in myeloid cells suppresses proinflammatory cytokine production and reduces collagen deposition. However, its role in methionine- and choline-deficient (MCD) diet-fed mice remains unclear. This study investigates the effects of myeloid-specific STAT3 deficiency on hepatic inflammation and fibrosis in MCD diet-fed mice. Myeloid-specific STAT3 knockout (mSTAT3KO) mice were fed the MCD diet for four weeks to induce metabolic...

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Coptidis rhizoma ameliorates type 2 diabetes mellitus-related metabolic dysfunction-associated steatohepatitis by downregulating the IL-17RA/NF-kappaB signaling pathway

October 2025

CONCLUSION: Coptidis rhizoma ameliorates pathological phenotypes in T2DM-related MASH by inhibiting the IL-17RA/NF-κB signaling pathway, and its active metabolite epiberberine is involved in mediating these protective effects.

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Arctigenin Prevents Metabolic Dysfunction-associated Steatohepatitis by Inhibiting NLRP3/GSDMD-N Axis in Macrophages

October 2025

CONCLUSIONS: ATG may inhibit the inflammatory cascade primarily by targeting macrophage NLRP3 inflammasomes, thereby preventing the progression of MASH.

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Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis

October 2025

Metabolic dysfunction-associated steatohepatitis (MASH) is a complex disease driven by multiple metabolic and inflammatory pathways. HSD17B13 is a potential therapeutic target for MASH, and PPAR regulates multiple pathological mechanisms related to MASH. Based on their important roles, we hypothesize that the HSD17B13/PPAR multitarget modulator may have a better effect in targeting multiple pathological mechanisms of MASH. In this study, a structure-based hybrid strategy was performed by...

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ApoJ and apoL1 as novel determinants of MASH: a cross-sectional study

October 2025

CONCLUSIONS: Plasma apoJ and apoL1 may serve as potential biomarkers for diagnosing MASH in individuals with obesity, independent of traditional risk factors. Further validation in larger cohorts and mechanistic studies is warranted.

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Bioactive compounds and multitarget action mechanism of Erzhi pills in alleviating metabolic dysfunction-associated steatohepatitis

October 2025

CONCLUSION: This study is the comprehensive elucidation of the active ingredients and mechanism of action behind EZP in its anti-MASH properties. EZP, as well as the combination of Sal and Ech are potential treatment for MASH that targets multiple signaling pathways.

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A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity

October 2025

Obesity and its sequelae cause significant morbidity and mortality worldwide. Current glucagon-like peptide-1 (GLP-1) receptor agonist-based treatments have significant side-effects associated with high rates of treatment discontinuation. Such concerns are greater still in children and adolescents. Thus, there remains a clinical unmet need to develop obesity and/or T2D mellitus therapies with significantly improved tolerability. Herein, we examined a polypharmacy approach combining melanocortin...

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Mechanisms of innate immune cells in Metabolic dysfunction-associated steatotic liver disease

October 2025

With the continuous increase of the incidence of Metabolic dysfunction-associated steatotic liver disease(MASLD), the proportion of MASLD-driven hepatocellular carcinoma(HCC) is gradually increasing, which will become a heavy burden on global public health. This article summarizes the existing literature and discusses the role of various innate immune cells in the occurrence and development of MASLD, such as cell-cell crosstalk, and uses bibliometric analysis to find current research hotspots...

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Waitlist Mortality in Candidates Listed for Liver Transplant in Females Varies by Liver Disease Aetiology

October 2025

CONCLUSION: 90-Day waitlist mortality in females is lower for ALD and higher for MASH and CCLD.

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Full Active Nanoplatform Restores ROS Homeostasis for Synergistic Therapy of Fatty Liver Disease via Dual Endogenous-Exogenous Pathways

October 2025

The therapeutic potential of nanomaterials in metabolic dysfunction-associated steatohepatitis (MASH) management remains limited by suboptimal drug loading efficiency and insufficient modulation of the disease's multifactorial pathogenesis. To address these issues, we developed a fully active pharmaceutical ingredient (API)-based nanodrug designed for synergistic MASH therapy through three integrated mechanisms: dual modulation of reactive oxygen species (ROS) homeostasis via endogenous and...

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Healthy mitochondria attenuate metabolic dysfunction-associated steatohepatitis by restoring cell metabolism

October 2025

Metabolic dysfunction-associated steatohepatitis (MASH) has become a major global health issue. Mitochondrial damage plays a crucial role in the development and progression of MASH. Therefore, it is speculated that mitochondrial transplantation therapy, which could replace dysfunctional mitochondria with normal ones, might potentially restore the liver cell metabolism of MASH. In palmitate-damaged AML-12 hepatocytes, exogenous mitochondria could eliminate lipid deposits and recover cell...

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Placebo Rates in Metabolic Dysfunction-associated Steatohepatitis Clinical Trials: A Systematic Review and Meta-analysis

October 2025

CONCLUSION: Placebo response rates among patients with MASH are generally elevated yet vary considerably depending on the outcome measured. This study provides valuable insights to enhance the design of future MASH trials.

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Semaglutide for the treatment of MASH: reaching into the ESSENCE of cardio-metabolic health?

October 2025

Metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis poses a significant clinical challenge, especially given its strong association with obesity and type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated impressive results in managing obesity and T2DM, prompting interest in their potential therapeutic role for MASH with fibrosis. The ESSENCE trial recently investigated the effectiveness of once-weekly semaglutide in patients with...

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Consensus position statements for the standardized application of histological grading and staging systems in MASH clinical trials

October 2025

CONCLUSION: The IMPG statements provide for the first time guidelines to promote consensus among liver pathologists for the histopathological evaluation and scoring of liver biopsies for MASH clinical trials. Furthermore, they may be used to inform supervised machine learning algorithms for quantitative MASLD histology assessments.

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Hepatocellular Carcinoma: from Screening to Therapy

October 2025

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related death worldwide. The incidence is increasing globally, primarily due to the rising prevalence of chronic liver diseases. While chronic viral hepatitis (HBV, HCV) and alcohol abuse have traditionally been considered the main risk factors, metabolic dysfunction-associated steatohepatitis (MASH) is increasingly gaining importance, especially in Western industrialized nations. In the vast...

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